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KMID : 0624620220550080395
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BMB Reports
2022 Volume.55 No. 8 p.395 ~ p.400
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2-Undecanone derived from Pseudomonas aeruginosa modulates the neutrophil activity
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Jeong Yu-Sun
Huh Sung-Hyun
Kim Ji-Cheol
Park Ji-Ye
Lee Chae-Eun
Kim Min-Sik
Koo Jae-Hyung
Bae Yoe-Sik
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Abstract
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Pseudomonas aeruginosa (P. aeruginosa) is a well-known Gramnegative opportunistic pathogen. Neutrophils play key roles in mediating host defense against P. aeruginosa infection. In this study, we identified a metabolite derived from P. aeruginosa that regulates neutrophil activities. Using gas chromatography-mass spectrometry, a markedly increased level of 2-undecanone was identified in the peritoneal fluid of P. aeruginosa-infected mice. 2-Undecanone elicited the activation of neutrophils in a Gαi-phospholipase C pathway. However, 2-undecanone strongly inhibited responses to lipopolysaccharide and bactericidal activity of neutrophils against P. aeruginosa by inducing apoptosis. Our results demonstrate that 2-undecanone from P. aeruginosa limits the innate defense activity of neutrophils, suggesting that the production of inhibitory metabolites is a strategy of P. aeruginosa for escaping the host immune system.
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KEYWORD
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2-undecanone, Bacterial metabolite, Neutrophil, Pseudomonas aeruginosa, Volatile organic compound
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